Invited review: Neisseria meningitidis lipopolysaccharides in human pathology

Heterogeneity and variation among Neisseria meningitidis lipopolysaccharides.

Eight immunotype lipopolysaccharides (LPSs) of Neisseria meningitidis were prepared by the phenol-water procedure and characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and sugar analyses. By SDS-PAGE and a highly sensitive silver strain. N. meningitidis LPSs from cells grown in tryptic soy broth were shown to contain one or two predominant components and a fe...

Neisseria meningitidis W135, Turkey

We describe the first case of Neisseria meningitidis W135 meningitis in Turkey. The strain was genotypically unrelated to the clone (W)ET-37, isolated from Hajj pilgrims in 2000.

Microaerobic denitrification in Neisseria meningitidis.

The major aetiological agent of human bacterial meningitis is Neisseria meningitidis. During the course of disease and host colonization, the bacterium has to withstand limited oxygen availability. Nitrogen oxide and nitrogen oxyanions are thought to be present, which may constitute an alternative sink for electrons from the N. meningitidis respiratory chain. A partial denitrification pathway i...

Neisseria meningitidis serotype W135.

Rifampin-resistant Neisseria meningitidis

To The Editor: Immediate management of meningococcal disease requires antimicrobial drug treatment of patients with β-lactams and chemo-prophylaxis of contact persons with rifampin. High-level resistance to rifampin (MIC >32 mg/L) in Neisseria meningitidis is provoked by mutations (most frequently at the residue His 552) in the rpoB gene encoding the β subunit of RNA poly-merase (1,2). Resistan...